2009 Fiscal Year Final Research Report
Molecular mechanisms of lipoprotein-sorting in Pseudomonas aeruginosa
| Project/Area Number |
20780050
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied microbiology
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| Research Institution | Kyoto University (2009)
The University of Tokyo (2008) |
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Principal Investigator |
NARITA Shin-Ichiro Kyoto University, ウイルス研究所, 特定助教 (30338751)
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| Research Collaborator |
TOKUDA Hajime 盛岡大学, 栄養科学部, 教授
ISHIMARU Kotomi 東京大学, 農学生命科学研究科, 大学院生
TERASAKI Takeshi 東京大学, 農学生命科学研究科, 大学院生
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| Project Period (FY) |
2008 – 2009
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| Keywords | 微生物学 / 細菌細胞表層 / 緑膿菌 / 薬剤耐性 / リポ蛋白質 |
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| Research Abstract |
Lipoproteins are located either in the inner or outer membranes of gram-negative bacteria such as Pseudomonas aeruginosa. Membrane localization of lipoproteins in P. aeruginosa is strictly determined by the residues at positions 3 and 4. To establish the sorting rule for lipoproteins in P. aeruinosa, combinations of amino acids at positions 3 and 4 that function as inner membrane retention signals for lipoproteins were selected. It turned out that charged residues such as Lys and Glu present at position 3 caused inner membrane retention of lipoproteins.
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[Book] Biogenesis and membrane targeting of lipoproteins.(EcoSal-Escherichia coli and Salmonella : Cellular and Molecular Biology.)(A.Bock, R.Curtiss III, J.B.Kaper, P.D.Karp, F.C.Neidhardt, T.Nystr?m, J.M.Slauch, C.L.Squires, and D.Ussery (ed.))(Chapter 4.3.7)(Washington, DC, USA)2010
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