2010 Fiscal Year Final Research Report
A novel network regulating the expression of PCB deRradation Renes.
| Project/Area Number |
20780059
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied microbiology
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| Research Institution | Tohoku Gakuin University |
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Principal Investigator |
MIYAUCHI Keisuke Tohoku Gakuin University, 工学部, 准教授 (20324014)
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| Project Period (FY) |
2008 – 2010
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| Keywords | PCB / 転写制御 / Rhodococcus / カタポライト抑制 |
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| Research Abstract |
The expression of polychlorinated biphenyls degradation genes in a PCB degrader, Rhodococcus jostii RHA1, is activated in the existence of biphenyl. This activation is repressed in the existence of intermediate metabolites which appear in the downstream pathway. In this study. we revealed that catechol is the metabolite which causes this repression. By making the metabolism flux from catechol smoothly, a PCB degrader which gives the constant degradation activity can be constructed.
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Research Products
(9 results)
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[Journal Article] Dual Two-Component Regulatory Systems Are Involved in Aromatic Compound Degradation in a Polychlorinated-Biphenyl Degrader, Rhodococcus jostii RHA1.2010
Author(s)
Takeda, H., Shimodaira, J., Yukawa, K., Hara, N., Kasai, D., Miyauchi, K., Masai, E., Fukuda, M.
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Journal Title
Journal of Bacteriology. 192
Pages: 4741-4751
Peer Reviewed
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