2009 Fiscal Year Final Research Report
Insulin signaling and lipid metabolism in fish
| Project/Area Number |
20780153
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Fisheries chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KANEKO Gen The University of Tokyo, 大学院・農学生命科学研究科, 助教 (30466809)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 代謝・酵素 / インスリン |
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| Research Abstract |
We cloned several genes possibly involved in lipid metabolism from torafugu and red seabream, and showed that their transcripts were predominant in tissues containing high quantities of lipid. Changes in expression of these genes suggested that lipid is transported mainly from liver to muscle in torafugu under starved conditions, whereas from adipose tissues to muscle in red seabream. cDNAs encoding hormones and their downstream signaling molecules related to lipid metabolism were also cloned and analyzed for their expression and tissue distribution.
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