2009 Fiscal Year Final Research Report
Analysis of defense system regulated by interferon-induced GTP binding proteins
| Project/Area Number |
20780208
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Tottori University |
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Principal Investigator |
ASANO Atsushi Tottori University, 農学部, 准教授 (90312404)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 地域日本語教室 / 日本語学習支援 / 外国人支援者 |
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| Research Abstract |
Interferon (IFN)-induced GTP binding proteins (GBPs) were thought to play a part in inhibition of amplification of infected viruses in animal. I identified two novel GBP genes, GBP2 and GBP3, of the chicken. The mRNA of these genes was induced by various IFNs such as IFNβ, IFNγ and IFNλ. Chicken GBP2 protein was located in the cytoplasm, which is similar to Mx, one of the antiviral GTP binding protein. Chicken GBP2 has the highest homology to human GBP1, which is an antiviral GBP, suggesting its antiviral property.
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