2009 Fiscal Year Final Research Report

Analysis of defense system regulated by interferon-induced GTP binding proteins

Research Project

Project/Area Number	20780208
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Basic veterinary science/Basic zootechnical science
Research Institution	Tottori University
Principal Investigator	ASANO Atsushi Tottori University, 農学部, 准教授 (90312404)
Project Period (FY)	2008 – 2009
Keywords	地域日本語教室 / 日本語学習支援 / 外国人支援者
Research Abstract	Interferon (IFN)-induced GTP binding proteins (GBPs) were thought to play a part in inhibition of amplification of infected viruses in animal. I identified two novel GBP genes, GBP2 and GBP3, of the chicken. The mRNA of these genes was induced by various IFNs such as IFNβ, IFNγ and IFNλ. Chicken GBP2 protein was located in the cytoplasm, which is similar to Mx, one of the antiviral GTP binding protein. Chicken GBP2 has the highest homology to human GBP1, which is an antiviral GBP, suggesting its antiviral property.

(2 results)