2009 Fiscal Year Final Research Report
Measurement/observation of special information during somitogenesis
| Project/Area Number |
20780241
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Applied molecular and cellular biology
|
|---|
| Research Institution | Nara Institute of Science and Technology |
|---|
Principal Investigator |
MATSUI Takaaki Nara Institute of Science and Technology, バイオサイエンス研究科, 助教 (60403333)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 発生 / 体節 / Hes / FGF |
|---|
| Research Abstract |
During vertebrate development, somites are generated by periodic segmentation. In this study, we investigated the relationship between segmentation clock (Hes) and special information (FGF). We show that Sprouty4 oscillates in mouse presomitic mesoderm, and that clock-dependent modulation of FGF signal activity acts as a determinant for future somite boundaries.
|
-
[Journal Article] Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the Notch segmentation clock in the mouse2009
Author(s)
Shinichi Hayashi, Taiju Shimoda, Masato Nakajima, Yuki Tsukada, Yuichi Sakumura, J. Kim Dale, Miguel Maroto, Kenji Kohno, Takaaki Matsui, Yasumasa Bessho
-
Journal Title
PSM PLoS One 4
Pages: e5603
Peer Reviewed
-
-
-
