2009 Fiscal Year Final Research Report
Synthesis of new seco-steroidal compounds, their use for steroidal biological evaluation, and development of new drug candidates
| Project/Area Number |
20790019
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
SAWADA Daisuke Teikyo University, 薬学部, 講師 (00338691)
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| Project Period (FY) |
2008 – 2009
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| Keywords | ビタミンD / プレビタミンD / 骨粗鬆症 |
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| Research Abstract |
In this project, I have synthesized and stably isolated the 14-epi-previtamin D3 analogs as new seco-steroidal compounds by synthetic chemical modification. Using these new analogs, I evaluated their biological properties, and have found a new lead compound for osteoporosis drug. Also, I was able to have preliminary results for the evaluation of their nongenomic action. By the removal of 19-methyl group, I have discovered the isomerization from previtamin D3 to tachysterol skeleton, which could be a new drug candidate.
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[Journal Article] Synthesis of 2α-substituted-14-epi-previtamin D3 and its genomic activity2009
Author(s)
Daisuke Sawada, Tomoyuki Katayama, Yuya Tsukuda, Nozomi Saito, Masashi Takano, Hiroshi Saito, Ken-ichiro Takagi, Eiji Ochiai, Seiichi Ishizuka, Kazuya Takenouchi, Atsushi Kittaka
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Journal Title
Bioorg. Med. Chem. Lett. 19
Pages: 5397-5400
Peer Reviewed
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[Journal Article] Synthesis and Biological Activities of 14-epi-MART-10 and 14-epi-MART-11: Implications for Cancer and Osteoporosis Treatment2009
Author(s)
Atsushi Kittaka, Hideki Hara, MasashiTakano, Daisuke Sawada, Midori A.Arai, Kenichiro Takagi, TakayukiChida, Yoshifumi Harada, HiroshiSaito, Kazuya Takenouchi, SeiichiIshizuka, Keiko Hayashi, ShinichiIkushiro, Toshiyuki Sakaki, TakayukiSugiura, Tai C. Chen
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Journal Title
Anticancer Res. 29
Pages: 3563-3569
Peer Reviewed
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[Journal Article] Vitamin D Hormone: Structural Refinement of the Seco-Steroidal Skeleton and the Nuclear Receptor Mediated Biological Activity2008
Author(s)
Atsushi Kittaka, Daisuke Sawada, Masashi Takano, Nozomi Saito, Tomoyuki Katayama, Kanako Shindo, Yuya Tsukuda, Shinobu Honzawa, Midori A. Arai, Hiroshi Saito, Ken-ichiro Takagi, Kazuya Takenouchi, Seiichi Ishizuka, Toshiyuki Sakaki, Tai C. Chen
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Journal Title
Anticancer Res. 28
Pages: 1611-1612
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