2009 Fiscal Year Final Research Report
Development of bioactive peptide derivative and dry powder inhalation system for treatment of COPD
| Project/Area Number |
20790103
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | University of Shizuoka |
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Principal Investigator |
ONOUE Satomi University of Shizuoka, 薬学部, 准教授 (00457912)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 慢性閉塞性肺疾患 / 血管作働性腸管ペプチド / 粉末吸入製剤 |
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| Research Abstract |
We developed some VIP derivative with improved stability, and dry powder inhaler system of VIP derivative was also designed for inhalation therapy. Intratracheal administration of VIP-based respirable powder led to significant attenuation of inflammatory events in COPD model rats.
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