2010 Fiscal Year Final Research Report

Design, synthesis, and evaluation of novel 5'-modified nucleoside analogs as anti-HCV agents

Research Project

Project/Area Number	20790106
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Drug development chemistry
Research Institution	Otani Womens University
Principal Investigator	IKEJIRI Masahiro Otani Womens University, 薬学部, 講師 (00412396)
Research Collaborator	OHSHIMA Takayuki 徳島文理大学, 香川薬学部, 准教授 MARUYAMA Tokumi 徳島文理大学, 香川薬学部, 教授
Project Period (FY)	2008 – 2010
Keywords	医薬品化学
Research Abstract	Hepatitis C is an infectious disease affecting the liver, caused by the hepatitis C virus. In Japan, there are many patients suffering from the disease. Common medicines are effective to some extent, but not enough. Thus, I planned to study on the synthesis of novel compounds designed originally aiming to produce a new medicine. Unfortunately, the chemicals obtained were not so effective to the virus. However, interestingly, I found that they are likely to operate via a new type of mechanism that is different from that of the common antiviral drugs.

(3 results)