Establishment of optimal conversion ratios of opioid analgesics based on genetic polymorphisms in individual palliative care

2010 Fiscal Year Final Research Report

• Project/Area Number: 20790132
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Medical pharmacy
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: NAITO Takafumi Hamamatsu University School of Medicine, 医学部附属病院, 副薬剤部長 (80422749)
• Project Period (FY): 2008 – 2010
• Keywords: オピオイド / がん性疼痛 / オーダーメード医療 / 遺伝子多型 / オピオイドローテーション / 緩和医療

Research Abstract

Opioid switching is useful for the improvement of pain control, the avoidance of opioid-induced adverse reaction and tolerance formation, and the change of administration route in patients with cancer pain. This study developed the conversion ratios of oral oxycodone to transdermal fentanyl based on genetic polymorphisms of the drug-metabolizing enzymes, drug transporter, and opioid receptor in cancer patients.

Research Products

• [Journal Article] CYP3A5*3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone. (2011)
  • Author(s): Naito T, Takashina Y, Yamamoto K, Tashiro M, Ohnishi K, Kagawa Y, Kawakami J.
  • Journal Title: J Clin Pharmacol in press
• [Journal Article] Validated LC coupled to ESI-MS/MS analysis for fentanyl in human plasma and UV analysis in applied reservoir transdermal patches using a simple and rapid procedure. (2009)
  • Author(s): Takashina Y, Naito T, Mino Y, Kagawa Y, Kawakami J.
  • Journal Title: J Clin Pharm Ther 34 Pages: 523-529
• [Presentation] がん患者におけるフェンタニル貼付剤への切り替え後の鎮痛効果及び有害作用に及ぼすCYP3A5とABCB1の遺伝子変異の影響 (2011)
  • Author(s): 高科嘉章, 内藤隆文, 見野靖晃, 大西一功, 川上純一
  • Organizer: 第131回日本薬学会年会
  • Place of Presentation: 静岡
  • Year and Date: 20110300
• [Presentation] CYP3A5*3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone. (2010)
  • Author(s): Takashina Y, Naito T, Tashiro M, Yamamoto K, Ohnishi K, Kagawa Y, Kawakami J.
  • Organizer: 第4回次世代を担う医療薬科学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 20101100
• [Presentation] がん性疼痛緩和におけるオピオイド鎮痛薬の体内動態情報に基づく個別化投与量換算法の構築 (2010)
  • Author(s): 内藤隆文
  • Organizer: 第20回日本病院薬剤師会東海ブロック学術大会.平成22年度日本薬学会東海支部例会.合同学術大会2010
  • Place of Presentation: 静岡
  • Year and Date: 20101100
• [Presentation] CYP3A5*3 affects plasma disposition of noroxycodone and dose escalation in cancer patients. (2010)
  • Author(s): Naito T, Yamamoto K, Takashina Y, Tashiro M, Kagawa Y, Ohnishi K, Kawakami J.
  • Organizer: 16th World Congress of Basic and Clinical Pharmacology (WorldPharma2010).
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 20100700
• [Presentation] Impact of CYP3A5 and ABCB1 gene polymorphisms on plasma disposition of fentanyl and its clinical responses in cancer patients with opioid switching to fentanyl transdermal system. (2010)
  • Author(s): Takashina Y, Naito T, Mino Y, Ohnishi K, Kawakami J.
  • Organizer: 16th World Congress of Basic and Clinical Pharmacology (WorldPharma2010).
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 20100700
• [Presentation] がん患者におけるオキシコドンの有害作用と耐性形成に及ぼすCYP3A5, CYP2D6およびOPRM1の遺伝子変異の影響 (2009)
  • Author(s): 山本圭祐, 内藤隆文, 高科嘉章, 丸山修治, 賀川義之, 川上純一
  • Organizer: 第30回日本臨床薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20091200
• [Presentation] がん患者におけるフェンタニルのマトリックス型とリザーバー型貼付剤間の経皮吸収および血中動態の比較 (2009)
  • Author(s): 高科嘉章, 内藤隆文, 八木達也, 山本圭祐, 山田尚広, 田中紀章, 門口直仁, 平野公美, 丸山修治, 川上純一
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2009
  • Place of Presentation: 四日市
  • Year and Date: 20091100
• [Presentation] フェンタニルのマトリックス型貼付剤中残存量の迅速測定法の開発:がん患者における経皮吸収動態の評価への応用 (2009)
  • Author(s): 高科嘉章, 内藤隆文, 八木達也, 山本圭祐, 丸山修治, 兼松直人, 川上純一
  • Organizer: 第19回日本医療薬学会年会
  • Place of Presentation: 長崎
  • Year and Date: 20091000