2009 Fiscal Year Final Research Report
Investigation of OFA-iLRP targeted cancer immunother apy against lung cancer
| Project/Area Number |
20790136
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ABE Shinji The University of Tokushima, 医学部・歯学部附属病院, 助教 (00403717)
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| Project Period (FY) |
2008 – 2009
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| Keywords | トランスレーショナルリサーチ / 癌 / 免疫療法 / 癌抗原 |
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| Research Abstract |
In this study, I have investigated whether OFA-iLRP is expressed on human lung cancer tissues and whether OFA-iLRP peptides treated dendritic cells induce OFA-iLRP specific CTLs. Our results show that most human lung cancer tissues express OFA-iLRP and dendritic cells treated by OFA-iLRP peptides induce CTLs. Considering these results, OFA-iLRP may represent a suitable target against advanced lung cancer.
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