2010 Fiscal Year Final Research Report
Analysis of epigenetic regulation of drug-metabolizing enzymes catalyzing anticancer drugs
| Project/Area Number |
20790142
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
SASAKI Takamitsu Tohoku Pharmaceutical University, 薬学部, 助手 (20382674)
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| Project Period (FY) |
2007 – 2010
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| Keywords | TPMT / エピジェネティクス / DHPLC / 抗癌剤代謝酵素 / 遺伝子多型 / 個人差 / マイクロRNA |
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| Research Abstract |
The purpose of this study was to investigate the regulatory mechanisms of TPMT gene expression and provide an information for future clinical studies regarding individual variations in drug efficacy and safety. We examined the relationship between TPMT activity and methylation of TPMT promoter or expression levels of microRNA. These results showed that TPMT activity was not significant effect on the regulatory mechanisms of methylation and microRNA. This study showed that individual variation of TPMT activity in human livers was associated with the present of genetic polymorphisms.
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[Journal Article] Genetic Variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese Individuals.2010
Author(s)
M Kudo, Y Saito, T Sasaki, H Akasaki, Y Yamaguchi, M Uehara, K Fujikawa, M Ishikawa, N Hirasawa, M Hiratsuka
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Journal Title
Drug Metab.Pharmacokinet. 24
Pages: 557-564
Peer Reviewed
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[Journal Article] Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57).2008
Author(s)
K Sakuyama, T Sasaki, S Ujiie, K Obata, M Mizugaki, M Ishikawa, M Hiratsuka
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Journal Title
Drug Metab.Dispos. 36
Pages: 2460-2467
Peer Reviewed
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