2009 Fiscal Year Final Research Report
Search for disturbance factor on pharmacokinetics and establishment of the methods of the rational use of drug in the patients with renal failure
Project/Area Number |
20790151
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Medical pharmacy
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Research Institution | Kyoto Pharmaceutical University |
Principal Investigator |
TSUJIMOTO Masayuki Kyoto Pharmaceutical University, 薬学部, 助教 (90372739)
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Project Period (FY) |
2008 – 2009
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Keywords | 薬物動態・代謝学 / 腎不全 |
Research Abstract |
In the patients with renal failure, it is known that the patients are decreasing not only renal clearance but also non-renal clearance. This study suggested that the decrease in non-renal clearance of antihypertensive drug losartan was induced by the inhibition of hepatic metabolism by uremic toxins, indoxyl sulfate and p-cresol. In addition, this study suggested that the decreased in non-renal clearance of lipid-lowering drug pravastatin was induced by the suppression of intestinal efflux transporter.
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Research Products
(10 results)
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[Journal Article] Inhibitory effects of ureamic toxins 3-indoxyl sulfate and p-cresol on losartan metabolism.2010
Author(s)
Tsujimoto M, Higuchi K, Shima D, Yokota H, Furukubo T, Izumi S, Yamakawa T, Otagiri M, Hirata S, Takara K, Nishiguchi K
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Journal Title
J Pharm Pharmacol 62
Pages: 133-138
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