2009 Fiscal Year Final Research Report
Immunohistochemical studies of water channel, aquaporins, in the brain.
| Project/Area Number |
20790160
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Nippon Medical School |
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Principal Investigator |
MATSUZAKI Toshiyuki Nippon Medical School, 医学部, 准教授 (30334113)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 水チャネル / アクアポリン / 脳 / 呼吸器 / 免疫組織化学 |
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| Research Abstract |
Detailed immunohistochemical localization of water channel, aquaporins, in the brain was examined to understand water transfer in the brain tissue. In addition to the previous studies which described that aquaporin-4 was restricted to the perivascular cell membrane of astrocytes, I revealed that aquaporin-4 was widely distributed on the plasma membrane of astrocytes. This result suggests that aquaporin-4 plays very important role in water handling in the brain. In addition, distribution of aquaporins was examined in the mouse tissue. I found that aquaporin-5 is more widely distributed in the mouse respiratory epithelium than that in the rat. Aquaporin-5 in the mouse respiratory epithelium seems to play an important role in maintaining the respiratory function.
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