2009 Fiscal Year Final Research Report
The effects of sex-specific, developmental stage-dependent environments on the declines of cognitive functions followed by aging
| Project/Area Number |
20790193
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Himeji Dokkyo University |
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Principal Investigator |
TAKASE Kenkichi Himeji Dokkyo University, 薬学部, 講師 (80381474)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 老化 / 環境 / 性差 / 認知 |
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| Research Abstract |
The purpose of this study is to identify the sex-specific dietary intake and momentum which prevent the decline of the activity in the cholinergic neurons from aging. In this research, we accidentally found that the male rats experiencing the undernutrition on postnatal day 9 and 11 showed social deficits without abnormalities in perception, motor functions, and cognitive functions. These abnormalities were not observed in females. These results suggest that the appropriate environments to develop brain functions are sex dependent, and that male rats are vulnerable to the undernutrition during infancy affecting the emotionality and sociality in adult life.
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[Presentation] 腎臓癌細胞における低酸素誘導VEGF発現増強はVHL非依存的経路を介する2010
Author(s)
Yamamoto Y, Takase K, Matsumoto J, Yoshida T, Nakamura T, Okamura N, Sakaeda T, Okumura K, Yagami T., 山本泰弘、高瀬堅吉、松本準、吉田泰三、中村任、岡村昇、栄田敏之、奥村勝彦、矢上達郎
Organizer
第83回日本薬理学会年会
Place of Presentation
大阪
Year and Date
20100300
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