2010 Fiscal Year Final Research Report
Chemical genetic study of the molecular mechanism for the regulation of osteoblast differentiation
| Project/Area Number |
20790218
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Microbial Chemistry Research Foundation |
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Principal Investigator |
SAKAMOTO Shuichi Microbial Chemistry Research Foundation, 微生物化学研究所沼津支所, 研究員 (60346070)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 化学遺伝学 / 間葉系幹細胞 / 骨芽細胞 / 天然低分子 / レチノイド |
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| Research Abstract |
Osteoblasts are the cells responsible for bone formation during embryonic development and adult life. Small compounds that could induce osteoblast differentiation might be promising sources of therapies for bone diseases such as osteoporosis. To identify inducers of early osteoblastic marker bone ALP in the pluripotent mesenchymal cells, in-house natural and synthetic chemical libraries were screened. Three small compounds were identified as active molecules and one of these compounds is a novel natural product with retinoid activity named decalpenic acid.
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[Journal Article] Decalpenic acid, a novel small molecule from Penicillium verruculosum CR37010, induces early osteoblastic markers in pluripotent mesenchymal cells.2010
Author(s)
Sakamoto,S., Kojima,F., Igarashi,M., Umekita, M., Sawa, R., Kubota, Y., Momose, I., Nakae, K., Yamaguchi, S., Adachi, H., Nishimura, Y., Akamatsu, Y.
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Journal Title
The Journal of Antibiotics. Vol.63
Pages: 703-708
Peer Reviewed
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