2009 Fiscal Year Final Research Report
Site-specific epigenetic regulation in cell fate decision of neural progenitor cells
| Project/Area Number |
20790230
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
KOHYAMA Jun Nara Institute of Science and Technology, バイオサイエンス研究科, 助教 (30437511)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 胚性幹細胞 / エピジェネティクス / DNAメチル化 |
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| Research Abstract |
During mammalian neural development, neural stem/progenitor cells sequentially change their differentiation potency ; they produce neurons during early neural development, and acquire potency to generate glial cells in later developmental stage.
Although epigenetic regulation including DNA methylation is considered to be involved in this step, detailed mechanism to regulate site specific epigenetic regulation of neural stem cell differentiation is still elusive. Here I demonstrated that Dnmt1 is deeply involved in this mechanism and Dnmt1 is further regulated by retinoic acid signaling.
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