2009 Fiscal Year Final Research Report

The analysis of NFκB regulation system

Research Project

Project/Area Number	20790234
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	General medical chemistry
Research Institution	Nagoya City University
Principal Investigator	ASAMITSU Kaori Nagoya City University, 大学院・医学研究科, 助教 (20381783)
Project Period (FY)	2008 – 2009
Keywords	生体分子医学 / NF-κB / 発現制御 / 転写
Research Abstract	Nuclear factor kB (NF-kB) is one of the critical transcription factors in inflammatory responses and cancer progression. In this study, we have identified FKBP4 as a binding partner of NF-kB p65 subunit and modified the NF-kB mediated transcription activity. FKBP4 is a binding protein to an immunosuppressive drug FK506 and known to involve with nuclear translocation. FKBP4 have enhanced NF-kB-dependent gene expression in combination with HSP90, suggesting that FKBP4 may be contributed to NF-kB translocation to the nucleus. The new regulation system of NF-kB via FKBP4 and HSP90 has been revealed.