The evaluation of Midkine as a therapeutic target in neuroblastoma model mice and the further search for other targets

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790251
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Nagoya University
• Principal Investigator: SATOSHI Kishida Nagoya University, 大学院・医学系研究科, 助教 (20402563)
• Project Period (FY): 2008 – 2009
• Keywords: 神経芽腫 / モデルマウス / ミッドカイン / 分子標的治療

Research Abstract

We evaluated the novel therapeutic target of neuroblastoma, a pediatric solid tumor, in model mice. We showed that Midkine, the gene we identified before, was involved in the tumorigenesis of neuroblastoma, and could be an effective target for molecular therapy. On the other hand, we searched the other genes involved in neuroblastoma by comprehensive expression analysis, and identified some potent candidates.

Research Products

• [Journal Article] Transforming growth factor-b1 upregulates keratan sulfate and chondroitin sulfate biosynthesis in microglias after brain injury (2009)
  • Author(s): Yin, J., Sakamoto, K., Zhang, H., Ito, Z., Imagama, S., Kishida, S., Natori, T., Sawada, M., Matsuyama, Y., Kadomatsu, K.
  • Journal Title: Brain Res., refereed 1263 Pages: 10-22
• [Journal Article] Plasma midkine level is a prognostic factor for human neuroblastoma. (2008)
  • Author(s): Ikematsu, S., Nakagawara, A., Nakamura, Y., Ohira, M., Shinjo, M., Kishida, S., Kadomatsu, K.
  • Journal Title: Cancer Sci., refereed 99 Pages: 2070-2074
• [Presentation] MYCN Tgマウスを用いたCGH及び発現アレイ解析による神経芽腫発生制御因子の探索. (2009)
  • Author(s): 岸田聡
  • Organizer: 第25回日本小児がん学会
  • Place of Presentation: 東京ベイホテル東急
  • Year and Date: 2009-11-27
• [Presentation] Genome-wide screen with CGH and gene expression array to identify novel factors involved in murine neuroblastoma model. (2009)
  • Author(s): 岸田聡
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-01
• [Presentation] Midkine is Involved in the Initiation and Progression of Neuroblastoma. (2008)
  • Author(s): Satoshi Kishida
  • Organizer: ANR2008
  • Place of Presentation: Makuhari Messe, Chiba, JAPAN
  • Year and Date: 20080521-20082524
• [Presentation] Midkine, a potent target of MYCN transcription factor, is involved in Neuroblastoma. (2008)
  • Author(s): 岸田聡
  • Organizer: BMB2008
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-12
• [Presentation] Midkine, a target of MYCN transcription factor, is involved in neuroblastoma development. (2008)
  • Author(s): 岸田聡
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-28