2009 Fiscal Year Final Research Report
A role of Nrf1 in the regulation of lipid metabolism
| Project/Area Number |
20790252
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Doshisha University |
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Principal Investigator |
TSUCHIYA Yoshiki Doshisha University, 生命医科学部, 助教 (30456777)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 代謝異常学 / 脂質代謝 |
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| Research Abstract |
To examine the physiological function of a transcription factor Nrf1 in the regulation of lipid metabolism, I tried to identify Nrf1-associated factors by using mass spectrometry. As a result, an E3 ubiquitin ligase subunit b-TrCP2 was identified. Further analyses revealed that b-TrCP2 regulates degradation of Nrf1 in the nucleus. These results provide a mechanistic insight into how Nrf1 is regulated to function in the target gene expression.
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