2009 Fiscal Year Final Research Report
Molecular basis of Nucleophosmin mutation in tumor
| Project/Area Number |
20790257
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Shimane University |
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Principal Investigator |
SAKASHITA Gyosuke Shimane University, 医学部, 助教 (00397457)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 分子病態学 |
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| Research Abstract |
Aurora-B phosphorylates NPM1 on S293 and S143 in vitro. However, phosphorylation of S143 was not detected in vivo. Phosphorylation of NPM1 on S293 does not involve in it's subcellular localization, oligomerization and interaction with known NPM1 binding protein such as p19ARF or Nucleolin.
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