2009 Fiscal Year Final Research Report
Characterization of annexin IV complex for new therapeutic development to ovarian clear cell adenocarcinoma
| Project/Area Number |
20790262
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
ARAKAWA Noriaki Yokohama City University, 生命ナノシステム科学研究科, 助教
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| Project Period (FY) |
2008 – 2009
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| Keywords | 分子腫瘍学 |
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| Research Abstract |
The protein annexin IV (ANX4) is elevated specifically and characteristically in ovarian clear cell adenocarcinoma (CCA), a highly malignant histological subtype of epithelial ovarian cancer. To clarify the functional and physiological role of the ANX4 protein in CCA, we conducted proteomic analyses to identify its binding partners. This analyses revealed that ANX4 formed a protein complex with several nucleic acid binding proteins.
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