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2009 Fiscal Year Final Research Report

Analysis of sulfotransferases involved in biosynthesis of selectin ligand carbohydrates in ulcerative colitis

Research Project

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Project/Area Number 20790278
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionShinshu University

Principal Investigator

KOBAYASHI Motohiro  Shinshu University, 医学系研究科, 講師 (00362137)

Project Period (FY) 2008 – 2009
Keywords潰瘍性大腸炎 / 翻訳後修飾 / 高内皮細静脈様血管 / MAdCAM-1 / セレクチンリガンド糖鎖
Research Abstract

A diffuse lymphocyte infiltrate characterizes ulcerative colitis, and requires at least one of the two molecular interactions: one via L-selectin and peripheral lymph node addressin (PNAd) and the other via α4β7 integrin and mucosal addressin cell adhesion molecule 1 (MAdCAM-1). The present study was undertaken to elucidate the role of post-translational modification of MAdCAM-1 protein with L-selectin ligand carbohydrates in the pathogenesis of ulcerative colitis. In this study, ulcerative colitis disease activity is not regulated by expression of MAdCAM-1 protein itself, but rather by decoration of MAdCAM-1 protein with L-selectin ligand carbohydrates mediated chiefly by sulfation by GlcNAc6ST-1.

  • Research Products

    (12 results)

All 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (6 results)

  • [Journal Article] Tumor suppressor function of laminin-bindingα-dystroglycan requires a distinctβ3-N-acetylglucosaminyltransferase.2009

    • Author(s)
      Bao X, Kobayashi M, Hatakeyama S, Angata K, Gullberg D, Nakayama J, Fukuda MN, Fukuda M
    • Journal Title

      Proc Natl Acad Sci USA 106

      Pages: 12109-12114

    • Peer Reviewed
  • [Journal Article] Role of ASC in the mouse model of Helicobacter pylori infection.2009

    • Author(s)
      Benoit NB, Kobayashi M, Kawakubo M, Takeoka M, Sano K, Zou J, Itano N, Tsutsui H, Noda T, Sagara J, Fukuda M, Nakayama J, Taniguchi S
    • Journal Title

      J Histochem Cytochem 57

      Pages: 327-338

    • Peer Reviewed
  • [Journal Article] Role of sulfated O-glycans expressed by HEV-like vessels in pathogenesis of chronic inflammatory gastrointestinal diseases.2009

    • Author(s)
      Kobayashi M, Fukuda M, Nakayama J
    • Journal Title

      Biol Pharm Bull 32

      Pages: 774-779

    • Peer Reviewed
  • [Journal Article] Roles of mucin-type O-glycans in the pathogenesis of Helicobacter pylori infection.2009

    • Author(s)
      Kobayashi M, Lee H, Nakayama J, Fukuda M
    • Journal Title

      Glycobiology 19

      Pages: 453-461

    • Peer Reviewed
  • [Journal Article] Carbohydrate-dependent defense mechanisms against Helicobacter pylori infection.2009

    • Author(s)
      Kobayashi M, Lee H, Nakayama J, Fukuda M
    • Journal Title

      Curr Drug Metab 10

      Pages: 29-40

    • Peer Reviewed
  • [Journal Article] GlcNAc6ST-1-mediated decoration of MAdCAM-1 protein with L-selectin ligand carbohydrates directs disease activity of ulcerative colitis.2009

    • Author(s)
      Kobayashi M, Hoshino H, Masumoto J, Fukushima M, Suzawa K, Kageyama S, Suzuki M, Ohtani H, Fukuda M, Nakayama J
    • Journal Title

      Inflamm Bowel Dis 15

      Pages: 697-706

    • Peer Reviewed
  • [Presentation] The HECA-452-positive but MECA-79-negative immunohistochemical profile of HEV-like vessels is characteristic for the diagnosis of gastric MALT lymphoma.2009

    • Author(s)
      Kobayashi M, Mitoma J, Fukuda M, Nakayama J
    • Organizer
      Annual Conference of the Society for Glycobiology
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      20090000
  • [Presentation] Primary colonic signet-ring cell carcinoma presenting carcinocythemia: an autopsy case.2009

    • Author(s)
      小林基弘, 伊藤誠, 岩谷舞
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      20090000
  • [Presentation] Decoration of MAdCAM-1 protein with L-selectin ligand carbohydrate mediated by GlcNAc6ST-1 directs disease activity of ulcerative colitis.2008

    • Author(s)
      Kobayashi M, Hoshino H, Masumoto J, Fukushima M, Suzawa K, Fukuda M, Nakayama J
    • Organizer
      Annual Conference of the Society for Glycobiology
    • Place of Presentation
      Fort Worth, TX, USA
    • Year and Date
      20080000
  • [Presentation] Laminin-binding glycans attached toα-dystroglycan function as a novel tumor suppressor.2008

    • Author(s)
      Bao X, Kobayashi M, Hatakeyama S, Yu SY, Angata K, Gullberg D, Khoo KH, Nakayama J, Fukuda MN, Fukuda M
    • Organizer
      Annual Conference of the Society for Glycobiology
    • Place of Presentation
      Fort Worth, TX, USA
    • Year and Date
      20080000
  • [Presentation] Preferential glycosylation of MAdCAM-1 on high endothelial venule-like vessels in ulcerative colitis.2008

    • Author(s)
      小林基弘, 福島万奈, 大谷明夫, 中山淳
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      20080000
  • [Presentation] Preferential induction of PNAd on HEV-like vessels in active phase of ulcerative colitis.2008

    • Author(s)
      酒井康弘, 小林基弘, 大谷明夫, 中山淳
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      20080000

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Published: 2011-06-18   Modified: 2016-04-21  

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