2009 Fiscal Year Final Research Report
Identification and characterization of WDR6, a novel insulin signaling molecule
| Project/Area Number |
20790306
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Nagasaki University |
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Principal Investigator |
CHIBA Takuya Nagasaki University, 大学院・医歯薬学総合研究科, 准教授 (40336152)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 老化 / インスリンシグナル / カロリー制限 / 視床下部 / 代謝 / 寿命 / 神経内分泌 |
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| Research Abstract |
We have isolated WD-repeat protein 6 (WDR6), a novel hypothalamus enriched gene in rat brain tissue. Amino acid sequence revealed that WDR6 have protein phosphatase motif and WD-repeat motif that have important roles for dephosphorylation and protein-protein interaction, respectively. Our study revealed that WDR6 physically interacted with insulin receptor substare-4 (IRS-4), which is abundantly expressed in the hypothalamus. These results suggest that WDR6 could regulate insulin/IGF-I signal in brain. Further study on WDR6 functions might contribute to the development of drugs for the treatment of neurodegenerative diseases, such as cognitive disorders.
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[Journal Article] Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain: implications for longevity.2009
Author(s)
Chiba T, Inoue D, Mizuno A, Komatsu T, Fujita S, Kubota H, Guimaraes M, Park S, Trindade L, Hayashida T, Hayashi H, Yamaza H, Higami Y, Shimokawa I
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Journal Title
Neurobiol Aging 30(3)
Pages: 474-82
Peer Reviewed
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[Journal Article] Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8.2008
Author(s)
Komatsu T, Chiba T, Yamaza H, Yamashita K, Shimada A, Hoshiyama Y, Henmi T, Ohtani H, Higami Y, de Cabo R, Ingram DK, Shimokawa I
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Journal Title
Exp Gerontol 43(4)
Pages: 339-46
Peer Reviewed
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