Comprehensive analysis of function of mDia family proteins in lymphocytes

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790372
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Kyoto University
• Principal Investigator: SAKATA Daiji Kyoto University, 医学研究科, 研究員 (70456870)
• Project Period (FY): 2008 – 2009
• Keywords: mDia / アクチン / リンパ球 / 免疫 / 遺伝子欠損マウス

Research Abstract

Actin protein are polymerized and work as a cytoskeleton in cells, and then regulates cell shape. mDia proteins are actin nucleating proteins, which consist of three types of mDia proteins, mDia1, mDia2, and mDia3. We made mice deficient in each type of mDia protein and examined roles of mDia proteins in the body. We found that certain immune responses are impaired in these mDia deficient mice.

Research Products

• [Journal Article] Prostaglandin E2, An immunoactivator (2010)
  • Author(s): Sakata D., Yao C., Narumiya S.
  • Journal Title: J. Pharm. Sci. 112巻 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Prostaglandin F2α-FP signaling facilitates bleomycin-induced pulmonary fibrosis independently of TGF-β (2009)
  • Author(s): Oga T., Matsuoka T., Yao C., Nonomura K., Kitaoka S., Sakata D., Kita Y., Tanizawa K., Taguchi Y., Chin K., Mishima M., Shimizu T., Narumiya S.
  • Journal Title: Nat. Med. 15巻 Pages: 1426-1430
  • Peer Reviewed
• [Journal Article] Prostaglandin E2-EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 expansion (2009)
  • Author(s): Yao C., Sakata D., Esaki Y., Li Y., Matsuoka T., Kuroiwa K., Sugimoto Y., Narumiya S.
  • Journal Title: Nat. Med. 15巻 Pages: 633-640
  • Peer Reviewed
• [Journal Article] T細胞の遊走とアクチン再編成 (2008)
  • Author(s): 坂田大治
  • Journal Title: 臨床免疫・アレルギー科 50巻 Pages: 265-270
• [Presentation] Dual role of the PGE2-EP4 signaling in mouse EAE model (2010)
  • Author(s): 坂田大治
  • Organizer: 第83回日本薬理学会
  • Place of Presentation: 大阪グランキューブ
  • Year and Date: 2010-03-17
• [Presentation] Prostaglandin E2-EP4 signaling facilitates bleomycin-induced pulmonary fibrosis independently of TGF-β (2009)
  • Author(s): Daiji Sakata
  • Organizer: The 9th world congress on inflammation
  • Place of Presentation: Keio Plaza Hotel, Tokyo
  • Year and Date: 20090707-20090709