2009 Fiscal Year Final Research Report
Cross-regulatory mechanisms of innate immunity and autophagy
| Project/Area Number |
20790376
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Kyushu University |
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Principal Investigator |
TAKAESU Giichi Kyushu University, 医学部, 講師 (60403995)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 自然免疫 / オートファジー |
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| Research Abstract |
Autophagy is an intracellular bulk degradation system conserved among eukaryotes. In mammals, autophagy plays many physiological roles such as starvation response, protein quality control, host defense and so on. However, the molecular mechanisms of autophagy regulation are not well understood. Here, I focused my study on cross-regulatorymechanisms of innate immunity and autophagy. I found that TAB2 and TAB3, previously characterized as adapter proteins involved in innate immunity, negatively egulate basal autophagy in mammalian cells.
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[Journal Article] A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses.2009
Author(s)
Saeki K, Fukuyama S, Ayada T, Nakaya M, Aki D, Takaesu G, Hanada T, Matsumura Y, Kobayashi T, Nakagawa R, Yoshimura A.
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Journal Title
J Immunol. 182(10)
Pages: 5929-5937
Peer Reviewed
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