Effect of cognitive function mediated by NMDA receptor activation of new nootropic drug.

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790398
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied pharmacology
• Research Institution: Tohoku University
• Principal Investigator: MORIGUCHI Shigeki Tohoku University, 大学院・薬学研究科, 助教 (70374949)
• Project Period (FY): 2008 – 2009
• Keywords: NMDA受容体 / 記憶学習 / CaMKII / PKC / アルツハイマー

Research Abstract

In this present study, we demonstrated that nefiracetam mediates cognitive function through activation of CaM kinase II (Moriguchi et al., J. Neurochem. 2008), and nefiracetam augments the impairment of coginitive function through activation of CaM kinase II and PKC in olfactory bulbectomized mice (Moriguchi et al., J. Neurochem. 2009), and nefiracetam enhances glutamatergic system via presynaptic nicotinic acethylcholine receptors in rat cortical neurons (Moriguchi et al., Neuroscinece 2009), and galantamine mediates cognitive function through activation of CaM kinase II (Moriguchi et al., Hippocampus, 2009).

Research Products

• [Journal Article] Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation. (2009)
  • Author(s): Yui Yamamoto, Norifumi Shioda, Feng Han, Shigeki Moriguchi, Akira Nakajima, Akihito Yokosuka, Yoshihiro Mimaki, Yutaka Sashida, Tohru Yamakuni, Yasushi Ohizumi, Kohji Fukunaga
  • Journal Title: Brain Res. 1295 Pages: 218-229
  • Peer Reviewed
• [Journal Article] Nefiracetam activation of CaM kinase II and Protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice. (2009)
  • Author(s): Shigeki Moriguchi, Feng Han, Norifumi Shioda, Yui Yamamoto, Takeharu Nakajima, Osamu Nakagawasai, Takeshi Tadano, Jay Z Yeh, Toshio Narahashi, Kohji Fukunaga
  • Journal Title: J. Neurochem. 110 Pages: 170-181
  • Peer Reviewed
• [Journal Article] Nefiracetam and galantamine modulation of excitatory and inhibitory synaptic transmission via stimulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons. (2009)
  • Author(s): Shigeki Moriguchi, Xilong Zhao, William Marszalec, Jay Z Yeh, Kohji Fukunaga, Toshio Narahashi
  • Journal Title: Neuroscience 160 Pages: 484-491
  • Peer Reviewed
• [Journal Article] Galantamine enhancement of long-term potentiation is mediated by calcium/calmodulin-dependent protein kinase II and protein kinase C activation. (2009)
  • Author(s): Shigeki Moriguchi, Norifumi Shioda, Feng Han, Jay Z Yeh, Toshio Narahashi, Kohji Fukunaga
  • Journal Title: Hippocampus 19 Pages: 844-854
  • Peer Reviewed
• [Journal Article] CaM kinase II and protein kinase C activations mediate enhancement of long-term potentiation by nefiracetam in the rat hippocampal CA1 region. (2008)
  • Author(s): Shigeki Moriguchi, Norifumi Shioda, Feng Han, Toshio Narahashi, Kohji Fukunaga
  • Journal Title: J. Neurochem. 106 Pages: 1092-1103
  • Peer Reviewed
• [Journal Article] Spino[imidazo[1, 2-a]pyridine-3, 2-indan]-2(3H)-one (ZSET1446/ST101) treatment rescues olfactory bulbectomy-induced memory impairment by activating CaM kinase II and protein kinase C in mouse hippocampus. (2008)
  • Author(s): Feng Han, Norifumi Shioda, Shigeki Moriguchi, Yui Yamamoto, Alisar Ali Raie, Yoshimasa Yamaguchi, Masataka Hino, Kohji Fukunaga
  • Journal Title: J. Pharmacol. Exp. Ther. 326 Pages: 127-134
  • Peer Reviewed
• [Journal Article] Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus. (2008)
  • Author(s): Kentaro Matsuzaki, Kenichi Miyazaki, Seiichiro Sakai, Hiromu Yawo, Norihito Nakata, Shigeki Moriguchi, Kohji Fukunaga, Akihito Yokosuka, Yutaka Sashida, Yoshihiro Mimaki, Tohru Yamakuni, Yasushi Ohizumi
  • Journal Title: Eur. J. Pharmacol. 578 Pages: 194-200
  • Peer Reviewed
• [Journal Article] Downregulation of glutamate transporters is associated with elevation in extracellular glutamate concentration following rat microsphere embolism. (2008)
  • Author(s): Feng Han, Norifumi Shioda, Shigeki Moriguchi, Zheng-Hong Qin, Kohji Fukunaga
  • Journal Title: Neurosci. Lett. 430 Pages: 275-280
  • Peer Reviewed
• [Journal Article] The vanadium (IV) compound rescues septo-hippocampal cholinergic neurons from neurodegeneration in olfactory bulbectomized mice. (2008)
  • Author(s): Feng Han, Norifumi Shioda, Shigeki Moriguchi, Zheng-Hong Qin, Kohji Fukunaga
  • Journal Title: Neuroscience 151 Pages: 671-679
  • Peer Reviewed
• [Presentation] 嗅球摘出マウスにおけるドネペジルによるアセチルコリン神経保護作用 (2008)
  • Author(s): 山本由似、塩田倫史、韓峰、森口茂樹、福永浩司
  • Organizer: 第59回日本薬理学会北部会
  • Place of Presentation: 仙台
  • Year and Date: 20080912-20080914
• [Presentation] A novel cognitive enhancer, ZSET1446 improves olfactory bulbectomy-induced memory impairment through CaMKII and PKC activation in mouse hippocampus. (2008)
  • Author(s): Yui Yamamoto, Feng Han, Norifumi Shioda, Shigeki Moriguchi, Kohji Fukunaga
  • Organizer: XI Workshop on Apoptosis in Biology and Medicine
  • Place of Presentation: Sendai
  • Year and Date: 20080912-20080914
• [Presentation] Impairment of cognitive function via down-regulation of calcium/calmodulin-dependent protein kinase II in Na+/Ca2+ exchanger (NCX2) knock-out mice (2008)
  • Author(s): Shigeki Moriguchi, Feng Han, Satomi Kita, Issei Komuro. Takahiro Iwamoto, Kohji Fukunaga
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
  • Year and Date: 20080911-20080913
• [Presentation] 新しい作用機序を有する認知機能改善薬の創薬研究 (2008)
  • Author(s): 福永浩司森口茂樹、塩田倫史、山本由似、韓峰
  • Organizer: 薬理学サマーセミナー2008
  • Place of Presentation: 栃木
  • Year and Date: 20080908-20080910
• [Presentation] アルツハイマー治療薬ドネペジルはアセチルコリン神経保護作用を有する (2008)
  • Author(s): 山本由似、塩田倫史、韓峰、森口茂樹、福永浩司
  • Organizer: 霧島フォーラム
  • Place of Presentation: 大分
  • Year and Date: 20080829-20080831
• [Presentation] A novel cognitive enhancer rescues olfactory bulbectomy-induced memory impairment through stimulation of CaMKII and PKC signalings in mouse hippocampus. (2008)
  • Author(s): Fang Han, Norifumi Shioda, Shigeki Moriguchi, Yoshimasa Yamaguchi, Masataka Hino, Kohji Fukunaga
  • Organizer: International Conference on Alzheimer's Disease
  • Place of Presentation: Chicago USA
  • Year and Date: 20080726-20080731
• [Presentation] The vanadium (IV) compound ameliorates OBX-induced neurodegeneration of the septo-hippocampal cholinergic neurons through Akt and ERK pathways. (2008)
  • Author(s): Kohji Fukunaga, Feng Han, Shigeki Moriguchi, Norifumi Shioda
  • Organizer: International Conference on Alzheimer's Disease
  • Place of Presentation: Chicago USA
  • Year and Date: 20080726-20080731
• [Presentation] Potentiation of calcium/calmodulin-dependent protein kinase II benefits for cognitive enhancement in Alzheimer's disease patients. (2008)
  • Author(s): Shigeki Moriguchi, Feng Han, Norifumi Shioda, Toshio Narahashi, Kohji Fukunaga
  • Organizer: International Conference on Alzheimer's Disease
  • Place of Presentation: Chicago USA
  • Year and Date: 20080726-20080731
• [Presentation] ラット大脳皮質神経細胞の興奮性および抑制性神経伝達におけるガランタミンならびにネフィラセタムの効果 (2008)
  • Author(s): 森口茂樹、楢橋敏夫、福永浩司
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 20080709-20080711
• [Presentation] 脳虚血に伴うCaMKII活性低下は学習記憶障害に関与している (2008)
  • Author(s): 山本由似、塩田倫史、森口茂樹、中島昌、山國徹、大泉康、福永浩司
  • Organizer: 第10回ブレインサイエンス研究会
  • Place of Presentation: 福岡
  • Year and Date: 20080531-20080601
• [Presentation] 嗅球摘出マウスにおけるDonepezilによるアセチルコリン神経保護作用 (2008)
  • Author(s): 山本由似、塩田倫史、韓峰、森口茂樹、福永浩司
  • Organizer: 第47回日本薬学会東北支部大会
  • Place of Presentation: 岩手
  • Year and Date: 2008-10-26
• [Presentation] 脳虚血に伴う学習記憶障害とCaMKII機能低下との関連性 (2008)
  • Author(s): 山本由似、塩田倫史、森口茂樹、中島昌、山國徹、大泉康、福永浩司
  • Organizer: 東北バイオサイエンス
  • Place of Presentation: 仙台
  • Year and Date: 2008-05-19