2010 Fiscal Year Final Research Report
Analysis of the brain pathophysiology in chronic fatigue syndrome.
| Project/Area Number |
20790479
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
MORIYA Junji Kanazawa Medical University, 医学部, 助教 (70460368)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 東洋医学 / 慢性疲労症候群(Chronic Fatigue Syndrome) / Resveratrol |
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| Research Abstract |
Several accompanying symptoms reported by chronic fatigue syndrome (CFS) patients, suggest that the central nervous system (CNS) may be involved in the pathophysiology of the syndrome. We established a mouse model of chronic fatigue by 6 times injection of Brucella abortus (BA) antigen every 2 weeks. We have found that brain atrophy and reduced mRNA levels for hippocampal Bcl-2 and brain-derived neurotrophic factor (BDNF) mRNA were accompanied by lower spontaneous activity in the model.
Resveratrol (RSV), polyphenolic activator of sirtuin 1 (Sirt1) and active component of grapevines and peanuts, was used for the treatment of this model.
So we hypothesized that hippocampal structural and/or functional defects existed in our mouse model of chronic fatigue. Furthermore, treatment with RSV may improve fatigue, and reverse the abnormalities by anti-apoptotic activity and promoting neurogenesis.
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[Journal Article] The kampo medicines orengedokuto, bofutsushosan and boiogito have different activities to regulate gene expressions in differentiated rat white adipocytes : comprehensive analysis of genetic profiles.2008
Author(s)
J.Yamakawa, Y.Ishigaki, F.Takano, T.Takahashi, J.Yoshida, J.Moriya, T.Takata, T.Tatsuno, K.Sasaki, T.Ohta, T.Takegami, F.Yoshizaki
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Journal Title
Biol.Pharm.Bull. 31
Pages: 2083-2089
Peer Reviewed
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