2009 Fiscal Year Final Research Report
Chemosensitivity prediction of platinum-containing anticancer drugs with gene expression of copper transporter on cell membrane
| Project/Area Number |
20790482
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Hirosaki University |
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Principal Investigator |
TAKAHATA Takenori Hirosaki University, 大学院・医学研究科, 助教 (20333726)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 上部消化器官学(食道、胃、十二指腸) / 薬剤感受性 |
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| Research Abstract |
In cell line experiments, gene knockdown of ATP7A, ATP7B and hCTR1 by siRNA showed no statistically significant difference in chemosensitivity of cisplatin and oxaliplatin. And in clinical sample experiments, there was no significant difference between cancer tissue and normal tissue from cancer-bearing patients in DNA methylation, point mutation and mRNA expression of these copper transporter genes.
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[Journal Article] Disturbance of the growth hormone-like growth factor-1 axis associated with poor performance status in patients with solid tumors
Author(s)
Isamu Okamoto, Masaki Munakata, Masaki Miyazaki, Takenori Takahata, Yasushi Takamatsu, Osamu Muto, Kazuhiko Koike, Kunihiko Ishitani, Taketo Mukaiyama, Yuh Sakata, Kazuo Tamura
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Journal Title
Jpn J Cllin Oncol (in press)
Peer Reviewed
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