The role of helper T cells in Helicobacter infection

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790494
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Kobe University
• Principal Investigator: TAKAGAWA Tetsuya Kobe University, 医学研究科, 医学研究員 (20444614)
• Project Period (FY): 2008 – 2009
• Keywords: 感染症 / T細胞 / ヘリコバクター属細菌

Research Abstract

The aim of this study is to clarify the role of CD4+ T cells in the development of H.pylori induced gastric cancer. It has been revealed gradually that Th1 type immune responses play critical roles in the development of gastritis and gastric cancer by our studies. It is very important to clarify the detailed mechanisms of host immune responses against H.pylori infection, which leads to the advancement in the treatment strategy for H.pylori related diseases, such as the immunotherapy and the control of oncogenesis.

Research Products

• [Journal Article] Blumberg RS, Azuma T. FcγReceptor Regulation of Citrobacter rodentium Infection. (2008)
  • Author(s): Masuda A, Yoshida M, Shiomi H, Ikezawa S, Takagawa T, Tanaka H, Chinzei R, Ishida I, Morita Y, Kutsumi H, Inokuchi H, Wang S, Kobayashi K, Mizuno S, Nakamura A, Takai T
  • Journal Title: Infect Immun 76(4) Pages: 1728-37