2009 Fiscal Year Final Research Report
To discover a novel therapy for preventing atherosclerosis by modulating the interaction between endothelial cell s- monocytes
| Project/Area Number |
20790530
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kobe University |
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Principal Investigator |
YASUDA Tomoyuki Kobe University, 医学研究科, 医学研究員 (20457047)
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| Research Collaborator |
ISHIDA Tatsuro 神戸大学, 大学院・医学研究科, 准教授 (00379413)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 循環器・高血圧 / 細胞・組織 / 内科 |
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| Research Abstract |
Our aim is to analyze the effect of ESAM on the progression of atherosclerosis. We generated ESAM / apoE double knockout mice and analyzed atherosclerosis lesion size. We also generated ESAM expression reduced endothelial cell by SiRNA method. We found that ESAM inhibition reduced the invasion of monocytes through endothelial cells and ESAM deficiency reduced atherosclerosis in apoE knockout mice. ESAM inhibition might be a novel therapy for preventing atherosclerosis.
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[Journal Article] Endothelial cell-selective adhesion molecule modulates atherosclerosis through plaque angiogenesis and monocyte-endothelial interaction.2010
Author(s)
Inoue M, Ishida T, Yasuda T, Toh R, Hara T, Cangara HM, Rikitake Y, Taira K, Sun L, Kundu RK, Quertermous T, Hirata KI
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Journal Title
Microvasc Res. (Epub ahead of print)
Peer Reviewed
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