Bone-marrow mesenchymal stem cell therapy for vascular repair

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790554
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Showa University
• Principal Investigator: YOSHITAKA Lso Showa University, 医学部, 助教 (60384244)
• Project Period (FY): 2008 – 2009
• Keywords: 血管病 / 間葉系幹細胞 / 血管再生 / 動脈硬化 / 血管リモデリング

Research Abstract

The aim of this study was to develop bone-marrow mesenchymal stem cell (MSC) therapy for repair of atherosclerotic vascular diseases. Similar to endothelial progenitors, MSCs were mobilized into peripheral circulation in patients with acute myocardial infarction, and cultured MSCs differentiated into vascular lineage cells. In rodent vascular injury model, local administration of MSCs suppressed neointimal formation and promoted re-endothelialization. MSC-based vascular intervention appears to be a promising approach for treatment of atherosclerosis and restenosis after vascular injury.

Research Products

• [Journal Article] Impact of implanted bone marrow progenitor cell composition on limb salvage after cell implantation in patients with critical limb ischemia (2010)
  • Author(s): Iso Y, Soda T, Sato T, Sato R, Kusuyama T, Omori Y, Shoji M, Koba S, Katagiri T, Kobayashi Y, Suzuki H
  • Journal Title: Atherosclerosis 209 Pages: 167-72
  • Peer Reviewed
• [Journal Article] Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis (2009)
  • Author(s): Xu G, Watanabe T, Iso Y, Koba S, Sakai T, Nagashima M, Arita S, Hongo S, Ota H, Kobayashi Y, Miyazaki A, Hirano T
  • Journal Title: Circ Res 105 Pages: 500-10
  • Peer Reviewed
• [Journal Article] Increased plasma urotensin-II and carotid atherosclerosis are associated with vascular dementia (2009)
  • Author(s): Ban Y, Watanabe T, Suguro T, Matsuyama TA, Iso Y, Sakai T, Sato R, Idei T, Nakano Y, Ota H, Miyazaki A, Kato N, Hirano T, Ban Y, Kobayashi Y
  • Journal Title: Atheroscler Thromb 16 Pages: 179-87
  • Peer Reviewed
• [Journal Article] Serum hepcidin-20 is elevated during the acute phase of myocardial infarction (2009)
  • Author(s): Suzuki H, Toba K, Kato K, Ozawa T, Tomosugi N, Higuchi M, Kusuyama T, Iso Y, Kobayashi N, Yokoyama S, Fukuda N, Saitoh H, Akazawa K, Aizawa Y
  • Journal Title: Tohoku J Exp Med 218 Pages: 93-8
  • Peer Reviewed
• [Journal Article] High-dose granulocyte-colony stimulating factor promotes neointimal hyperplasia in the early phase and inhibits neointimal hyperplasia in the late phase after vascular injury (2008)
  • Author(s): Shoji M, Iso Y, Kusuyama T, Omori Y, Soda T, Tsunoda F, Sato T, Koba S, Geshi E, Kobayashi Y, Katagiri T, Suzuki H
  • Journal Title: Circ J 72 Pages: 1885-93
  • Peer Reviewed
• [Journal Article] Elevation of matrix metalloproteinases and interleukin-6 in the culprit coronary artery of myocardial infarction (2008)
  • Author(s): Suzuki H, Kusuyama T, Sato R, Yokota Y, Tsunoda F, Sato T, Shoji M, Iso Y, Koba S, Katagiri T
  • Journal Title: Eur J Clin Invest 38 Pages: 166-73
  • Peer Reviewed
• [Journal Article] G-CSF after myocardial infarction accelerates angiogenesis and reduces fibrosis in swine (2008)
  • Author(s): Sato T, Suzuki H, Kusuyama T, Omori Y, Soda T, Tsunoda F, Shoji M, Iso Y
  • Journal Title: Int J Cardiol 127 Pages: 166-173
  • Peer Reviewed
• [Presentation] CD271 Identifies Human Bone Marrow Stem/Progenitor Cells with a Proangiogenic Potential and Circulating Progenitor Cells Mobilized after Acute Myocardial Infarction (2010)
  • Author(s): Yoshitaka Iso, et al
  • Organizer: American College of Cardiology 2010
  • Place of Presentation: Atlanta, U.S. A
  • Year and Date: 20100314-20100316
• [Presentation] Impact of erythroblasts in bone marrow cells on limb salvage after cell implantation in patients with critical limb ischemia (2009)
  • Author(s): Yoshitaka Iso, et al
  • Organizer: European Society of Cardiology 2009
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20090829-20090902
• [Presentation] Cellular Composition in Bone Marrow Cells may Influence Limb Salvage after Cell Implantation in Patients with Critical Limb Ischemia (2009)
  • Author(s): Yoshitaka Iso, et al
  • Organizer: 第41回日本動脈硬化学会シンポジウム4
  • Place of Presentation: 下関
  • Year and Date: 20090717-20090718
• [Presentation] Circulating progenitors, angiotensinII and renal function in the elderly (2009)
  • Author(s): Yoshitaka Iso, et al
  • Organizer: 第73回日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 20090320-20090322
• [Presentation] Mobilization of Mesenchymal stem/progenitor cells after acute myocardial infarction (2009)
  • Author(s): Yoshitaka Iso, et al
  • Organizer: 第73回日本循環器学会
  • Place of Presentation: 大阪
  • Year and Date: 20090320-20090322
• [Presentation] Impact of Erythoid progenitors in bone marrow cells on limb salvage after cell implantation in patients with critical limb ischemia (2009)
  • Author(s): Yoshitaka Iso, et al
  • Organizer: 第8回日本再生医療学会
  • Place of Presentation: 東京
  • Year and Date: 20090305-20090306