2009 Fiscal Year Final Research Report
Regulation of VEGF expression by PPAR in human lung cancer cells
| Project/Area Number |
20790562
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
TANNO Sachie Asahikawa Medical College, 大学病院, 医員 (80455724)
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| Project Period (FY) |
2008 – 2009
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| Keywords | チアゾリジン誘導体 / 肺がん / collagen XVIII |
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| Research Abstract |
Thiazolidinedione (TZD) use in patients with diabetes was specifically associated with reduced risk of lung cancer. Since collagen XVIII is one of the strongest predictors of outcome in patients with lung cancer, we examined the effects of TZD on expression of collagen XVIII in human non-small lung cancer (NSCLC) cells. The present results results suggest for the first time that TZDs reduced expression of collagen XVIII in NSCLC, which may help us understand the mechanism why TZDs use has chemopreventive action.
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