2009 Fiscal Year Final Research Report
The investigation into the endocytosis-mediated effects of the steroid hormones in renal proximal tubular epithelial cells
| Project/Area Number |
20790589
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
SATO Hiroyoshi Niigata University, 大学院・医歯学総合研究科, 特任助教 (30413610)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 腎臓学 / 近位尿細管 / エンドサイトーシス / ホルモン |
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| Research Abstract |
I performed basic examination of possibility to have action through endocytosis of steroid hormone aldosterone etc in renal proximal tubular epithelial cells (PTEC), and I examined the expressional control of endocytotic receptor megalin by renin-angiotensin system (RAS) with a closely relation of aldosterone in PTEC. First, protein level of aldosterone receptor MR and aldosterone response gene SGK1 was confirmed in PTEC. Second, it was clarified the crosstalk with the insulin sinal that recovered the control of angiotensin II on the suppression of Megalin expression in PTEC.
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