2009 Fiscal Year Final Research Report
Identification of the origin of prion infection
| Project/Area Number |
20790608
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Tohoku University |
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Principal Investigator |
KOBAYASHI Atsushi Tohoku University, 大学院・医学系研究科, 助教 (50431507)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 神経病態生化学 / プリオン / クロイツフェルト・ヤコブ病 / 神経変性疾患 / 脳 |
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| Research Abstract |
We previously reported an atypical sCJD-MM1 case (MM1-PL) presenting many plaque-type PrP deposits in the brain. To investigate the origin of the MM1-PL, we performed intracerebral inoculation of a brain homogenate from the MM1-PL patient into humanized mice with 129M/M or 129V/V genotype. The present our study shows that the MM1-PL was caused by the iatrogenic transmission of sCJD-VV2 prions.
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