2009 Fiscal Year Final Research Report

Analysis of specificity of fatty acids beta-oxidation in the central nerve system

Research Project

Project/Area Number	20790629
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Neurology
Research Institution	Fujita Health University
Principal Investigator	OHKAWARA Takeshi Fujita Health University, 医学部, 助教 (20469034)
Project Period (FY)	2008 – 2009
Keywords	神経分子病態学 / エネルギー代謝
Research Abstract	The embryonic carcinoma P19 cells are a well established cell line commonly used as an in vitro neuronal differentiation model. I analyzed expression pattern of fatty acids beta-oxidation enzymes using this cell line through the process of neuronal differentiation. Immunocytochemical and real time PCR experiments showed that almost all fatty acids beta-oxidation enzymes are expressed in the neural precursor cells and neurons. In addition, expression levels of these enzymes were increased through the process of neuronal differentiation.

(2 results)