2009 Fiscal Year Final Research Report
Analysis of specificity of fatty acids beta-oxidation in the central nerve system
| Project/Area Number |
20790629
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Fujita Health University |
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Principal Investigator |
OHKAWARA Takeshi Fujita Health University, 医学部, 助教 (20469034)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 神経分子病態学 / エネルギー代謝 |
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| Research Abstract |
The embryonic carcinoma P19 cells are a well established cell line commonly used as an in vitro neuronal differentiation model. I analyzed expression pattern of fatty acids beta-oxidation enzymes using this cell line through the process of neuronal differentiation. Immunocytochemical and real time PCR experiments showed that almost all fatty acids beta-oxidation enzymes are expressed in the neural precursor cells and neurons. In addition, expression levels of these enzymes were increased through the process of neuronal differentiation.
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