2009 Fiscal Year Final Research Report
The molecular mechanism and physiological significance of thyroid hormone non-genomic action
| Project/Area Number |
20790658
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Nagoya University |
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Principal Investigator |
SOU Kasumi Nagoya University, 環境医学研究所, 助教 (70432218)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 甲状腺ホルモン / ノンゲノミック作用PI3K→Akt |
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| Research Abstract |
We have reported previously that thyroid hormone (T3) stimulates the PI3K/Akt pathway through thyroid hormone receptor (TR).It is a non-genomic action since the novel protein synthesis is not involved in. In the present study we demonstrated that T3 promotes the complex formation of TR/Src/p85, which induces the phosphorylation of Src and p85 sequentially and results in the activation of PI3K→Akt. This novel T3 action plays important role in neuronal cell survival.
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