2009 Fiscal Year Final Research Report
Cancer stem cell theory in thyroid carcinogenesis
| Project/Area Number |
20790662
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Nagasaki University |
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Principal Investigator |
MITSUTAKE Norisato Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (50404215)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 甲状腺 / 幹細胞 |
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| Research Abstract |
We have successfully developed a novel culture system to isolate stem-like cells from human normal thyroid tissues. These cells had differentiation potentials not only into thyroid follicular cells but also into neuron or adipocytes. The isolated cells may be directly reprogrammed from thyroid follicular cells, and this reprogramming might be involved in generating cancer stem cells during carcinogenesis.
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[Journal Article] Fagin JA 2009 Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene.2009
Author(s)
*Chen X, *Mitsutake N, LaPerle K, Akeno N, Zanzonico P, Longo VA, Mitsutake S, Kimura ET, Geiger H, Santos E, Wendel HG, Franco A, Knauf JA
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Journal Title
Proc Natl Acad Sci U S A 106
Pages: 7979-7984
Peer Reviewed
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[Journal Article] Dehydroxymethylepoxyquinomicin, a novel nuclear Factor-kappaB inhibitor, enhances antitumor activity of taxanes in anaplastic thyroid cancer cells.2008
Author(s)
Meng Z, Mitsutake N, Nakashima M, Starenki D, Matsuse M, Takakura S, Namba H, Saenko V, Umezawa K, Ohtsuru A, Yamashita S
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Journal Title
Endocrinology 149
Pages: 5357-5365
Peer Reviewed
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