2009 Fiscal Year Final Research Report
Analysis of functional regulatory mechanism of human hematopoietic stem cell by cyclin C
| Project/Area Number |
20790672
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Nagoya University |
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Principal Investigator |
MIYATA Yasuhiko Nagoya University, 医学部・附属病院, 医員 (40467303)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 造血幹細胞 / 細胞周期 / サイクリンC / 静止期 / 生着 |
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| Research Abstract |
We have identified an important role of cyclin C (CCNC) in regulating human hematopoietic stem/progenitor cell (HSPC) quiescence, as knocking down CCNC expression in human cord blood CD34+ cells resulted in a significant increase in quiescent cells that maintain CD34 expression. CCNC knockdown also promotes in vitro HSPC expansion and enhances their engraftment potential in sublethally irradiated immunode- ficient mice. Our studies establish cyclin C as a critical regulator of the G0/G1 transition of human HSPCs and suggest that modulating cyclin C levels may be useful for HSC expansion and more efficient engraftment.
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[Journal Article] Irrespective of CD34 expression, lineage-committed cell fraction reconstitutes and re-establishes transformed Philadelphia chromosome-positive leukemia in NOD / SCID / IL-2Rγc-/- mice.2010
Author(s)
Tanizaki R, Nomura Y, Miyata Y, Minami Y, Abe A, Hanamura A, Sawa M, Murata M, Kiyoi H, Matsushita T, Naoe T
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Journal Title
Cancer Science. 101
Pages: 631-8
Peer Reviewed
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