2009 Fiscal Year Final Research Report
Apoptosis control of hematopoietic cells throughthe regulation of mRNA stability and its involvement in leukemogenesis
| Project/Area Number |
20790675
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Hiroshima University |
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Principal Investigator |
MATSUI Hirotaka Hiroshima University, 原爆放射線医科学研究所, 助教 (60379849)
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| Project Period (FY) |
2008 – 2009
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| Keywords | Bim / Hsc70 / mRNA安定性制御 |
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| Research Abstract |
We identified cis-elements on Bim mRNA that would be bound by Hsc70-complex. These were almost 800bp long AU-rich sequences which were highly conserved between human and mouse. Furthermore, we isolated miRNA that bind to Bim mRNA. miR-181 seemed to bound to 200bp downstream of stop codon of Bim mRNA and to regulate the stability of Bim mRNA.
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[Journal Article] Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells2010
Author(s)
Okuya M, Kurosawa H, Kikuchi J, Furukawa Y, Matsui H, Aki D, Matsunaga T, Inukai T, Goto H, Altura RA, Sugita K, Arisaka O, Look AT, Inaba T
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Journal Title
J Biol Chem 285(3)
Pages: 1850-1860
Peer Reviewed
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