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2009 Fiscal Year Final Research Report

The development of immune regulation by genetically modified ES-DC

Research Project

  • PDF
Project/Area Number 20790693
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionKumamoto University

Principal Investigator

HIRATA Shinya  Kumamoto University, 大学院・医歯学総合研究科, 助教 (60418829)

Project Period (FY) 2008 – 2009
Keywords臨床免疫学 / 移植免疫学 / ES細胞由来樹状細胞 / 糖尿病 / 制御性T細胞 / TRAIL
Research Abstract

Recent studies showed that DCs physiologically play significant roles in regulating immune responses both positively and negatively. For genetic modification of DC, we used a previously established method to generate DC from mouse ES cells in vitro (ES-DC). We tried 1) the prevention of diabetes by transfer of ES-DC expressing islet-derived antigen along with immunosuppressive molecules in NOD mice, and 2) the prolongation of islet allograft survival by transfer of ES-DC expressing immunosuppressive molecules. These strategies may also be useful for the treatment of subjects with autoimmune diseases and for the induction of transplantation tolerance.

  • Research Products

    (19 results)

All 2010 2009 2008 Other

All Journal Article (15 results) (of which Peer Reviewed: 13 results) Presentation (2 results) Remarks (2 results)

  • [Journal Article] Pluripotent stem cells as source of dendritic cells for immune therapy.2010

    • Author(s)
      Senju, S., Hirata, S., Motomura, Y., Fukuma, D., Matsunaga, Y., Fukushima, S., Matsuyoshi, H., Nishimura, Y.
    • Journal Title

      Int J Hematol 91(3)

      Pages: 392-400

    • Peer Reviewed
  • [Journal Article] Identification of SPARC as a candidate target antigen for immunotherapy of various cancers.2010

    • Author(s)
      Inoue, M., Senju, S., Hirata, S., Ikuta, Y., Hayashida, Y., Irie, A,, Harao, M., Imai, K., Tomita, Y., Tsunoda, T., Furukawa, Y., Ito, T., Nakamura, Y., Baba, H., Nishimura, Y.
    • Journal Title

      Int J Cancer (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Efficient induction of human T-cell leukemia virus-l-specific CTL by chimeric particle without adjuvant as a prophylactic for adult T-cell leukemia.2009

    • Author(s)
      Kozako, T., Fukada, K., Hirata, S., White, Y., Harao, M., Nishimura, Y., Kino, Y., Soeda, S., Shimeno, H., Lemonnier, F., Sonoda, S., Arima, N.
    • Journal Title

      Mol Immunol 47

      Pages: 606-613

    • Peer Reviewed
  • [Journal Article] An in vivo model of priming of antigen-specific human CTL by Mo-DC in NOD/Shi-scid IL2rgamma(null) (NOG) mice.2009

    • Author(s)
      Inoue, M., Senju, S., Hirata, S., Irie, A., Baba, H., Nishimura, Y.
    • Journal Title

      Immunol Lett 126(1-2)

      Pages: 67-72

    • Peer Reviewed
  • [Journal Article] Multiple Antigen-targeted Immunotherapy With alpha-Galactosylceramide-loaded and Genetically Engineered Dendritic Cells Derived From Embryonic Stem Cells.2009

    • Author(s)
      Fukushima, S., Hirata, S., Motomura, Y., Fukuma, D., Matsunaga, Y., Ikuta, Y., Ikeda, T., Kageshita, T., Ihn, H., Nishimura, Y., Senju, S.
    • Journal Title

      J Immunother 32(3)

      Pages: 219-231

    • Peer Reviewed
  • [Journal Article] (*equal contribution) Identification of the H2-Kd-restricted cytotoxic T lymphocyte epitopes of a tumor-associated antigen, SPARC, which can stimulate antitumor immunity without causing autoimmune disease in mice.2009

    • Author(s)
      Ikuta, Y. *, Hayashida, Y. *, Hirata, S., Irie, A., Senju, S., Kubo, T., Nakatsura, T., Monji, M., Sasaki, Y., Baba, H., Nishimura, Y.
    • Journal Title

      Cancer Sci 100(1)

      Pages: 132-7

    • Peer Reviewed
  • [Journal Article] TRAIL発現樹状細胞によるレギュラトリーT細胞の誘導と実験的自己免疫性脳脊髄炎の治療2009

    • Author(s)
      平田真哉, 千住覚, 西村泰治
    • Journal Title

      臨床-免疫・アレルギー科(科学評論社(東京)) 51(1)

      Pages: 72-76

  • [Journal Article] Activation of antigen-specific cytotoxic T lymphocytes by beta 2-microglobulin or TAP1 gene disruption and the introduction of recipient-matched MHC class I gene in allogeneic embryonic stem cell-derived dendritic cells.2008

    • Author(s)
      Matsunaga, Y., Fukuma, D., Hirata, S., Fukushima, S., Haruta, M., Ikeda, T., Negishi, I., Nishimura, Y., Senju S.
    • Journal Title

      J Immunol 181(9)

      Pages: 6635-43

    • Peer Reviewed
  • [Journal Article] Identification of a novel tumor-associated antigen, cadherin 3/P-cadherin, as a possible target for immunotherapy of pancreatic, gastric, and colorectal cancers.2008

    • Author(s)
      Imai, K., Hirata, S., Irie, A., Senju, S., Ikuta, Y., Yokomine, K., Harao, M., Inoue, M., Tsunoda, T., Nakatsuru, S., Nakagawa, H., Nakamura, Y., Baba, H., Nishimura Y.
    • Journal Title

      Clin Cancer Res 14(20)

      Pages: 6487-95

    • Peer Reviewed
  • [Journal Article] HLA-A2-restricted CTL epitopes of a novel lung cancer-associated cancer testis antigen, cell division cycle associated 1, can induce tumor-reactive CTL.2008

    • Author(s)
      Harao, M., Hirata, S., Irie, A., Senju, S., Nakatsura, T., Komori, K., Ikuta, Y., Yokomine, K., Imai, K., Inoue, M., Harada, K., Mori, Y., Tsunoda, T., Nakatsuru, S., Daigo, Y., Nomori, H., Nakamura, Y., Baba, H., Nishimura, Y.
    • Journal Title

      Int J Cancer 123(11)

      Pages: 2616-25

    • Peer Reviewed
  • [Journal Article] Role of human non-invariant NKT lymphocytes in the maintenance of type 2 T helper environment during pregnancy.2008

    • Author(s)
      Uemura, Y., Suzuki, M., Liul, TY., Narita, Y., Hirata, S., Ohyama, H., Ishihara, O., Matsushita, S.
    • Journal Title

      Int Immunol 20(3)

      Pages: 405-12

    • Peer Reviewed
  • [Journal Article] Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells.2008

    • Author(s)
      Liu, TY., Uemura, Y., Suzuki, M., Narita, Y., Hirata, S., Ohyama, H., Ishihara, O., Matsushita, S.
    • Journal Title

      Eur J Immunol 38(4)

      Pages: 1012-23

    • Peer Reviewed
  • [Journal Article] ES-DC2008

    • Author(s)
      平田真哉, 千住覚, 西村泰治
    • Journal Title

      炎症と-免疫(先端医学社(東京)) 16(1)

      Pages: 133-135

  • [Journal Article] The transfer of ES cell-derived dendritic cells expressing TRAIL prolonged islets allograft survival.

    • Author(s)
      Hirata, S., Fukushima, S., Ikeda, T., Matsunaga, Y., Moriyama, H., Yokono, K., Nagata, M., Senju, S., Nishimura, Y.
    • Journal Title

      Transplantation (in revision)

    • Peer Reviewed
  • [Journal Article] Dual effects of TRAIL to suppress autoimmunity: the inhibition of Thl cells and thepromotion of regulatory T cells.

    • Author(s)
      Ikeda, T., Hirata, S., Fukushima, S., Matsunaga Y., Ito, T., Uchino, M., Nishimura, Y., Senju, S.
    • Journal Title

      J Immunol (in revmision)

    • Peer Reviewed
  • [Presentation] TRAILを発現するアロES-DCの投与によるアロ膵島に対する拒絶反応の抑制2008

    • Author(s)
      平田真哉, ら
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      20081201-20081203
  • [Presentation] 免疫抑制性分子を遺伝子導入したマウスES細胞由来の樹状細胞の同種異系(アロ)移植への応用2008

    • Author(s)
      平田真哉, ら
    • Organizer
      第36回日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      20081017-20081018
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/grad/rheu/rheu-J.htm

  • [Remarks]

    • URL

      http://www.medic.kumamoto-u.ac.jp/dept/immunoge/immunoge.html

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Published: 2011-06-18   Modified: 2016-04-21  

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