2009 Fiscal Year Final Research Report
The role of neurotransmitter in DC-T cell interaction and new strategy for treatment of RA
| Project/Area Number |
20790704
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
NAKANO Kazuhisa University of Occupational and Environmental Health, Japan, 医学部, 助教 (50406500)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 関節リウマチ / ドパミン / T細胞分化 / 樹状細胞 |
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| Research Abstract |
We revealed that dendritic cells (DCs) were one of sources of dopamine in the synovial tissue of RA. During antigen-specific interaction with naive T-cells, dopamine released by DCs bound to D1-like dopamine receptors, induced differentiation to Th17 cells via IL-6 production. D2-like receptor-antagonists significantly induced accumulation of IL-6- and IL-17- positive T cells with remarkable angiogenesis, increased multiple layers of synovial fibroblast and exacerbated cartilage destruction in SCID-HuRAg mice, whereas antagonizing D1-like-receptor suppressed these responses.
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