Research on leptin in systemic autoimmune disease

2010 Fiscal Year Final Research Report

• Project/Area Number: 20790707
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Department of Clinical Research, National Hospital Organization Utano National Hospital
• Principal Investigator: FUJITA Yoshimasa Department of Clinical Research, National Hospital Organization Utano National Hospital, 医学部, 講師 (70450880)
• Project Period (FY): 2008 – 2010
• Keywords: 内科 / 免疫学

Research Abstract

Lupus nephritis was ameliorated in leptin deficient MRL/lpr mice. Leptin inhibited stress-induced apoptosis of bone marrow B cells in vivo, through indirect effects such as endocrine and metabolic system.

Research Products

• [Journal Article] Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease. (2010)
  • Author(s): Sato T, Fujii T, Yokoyama T, Fujita Y, Imura Y, Yukawa N, Kawabata D, Nojima T, Ohmura K, Usui T, Mimori T.
  • Journal Title: Arthritis Rheum. 62(12) Pages: 3730-3740
  • Peer Reviewed
• [Journal Article] Synergistic effects of topoisomerase I inhibitor, SN38, on Fas-mediated apoptosis. (2010)
  • Author(s): Cao Y, Jin ZX, Tong XP, Yue S, Sakai T, Kawanami T, Sawaki T, Miki M, Iwao H, Nakajima A, Masaki Y, Fukushima Y, Fujita Y, Nakajima H, Okazaki T, Umehara H.
  • Journal Title: Anticancer Res. 30(10) Pages: 3911-3917
  • Peer Reviewed
• [Journal Article] Complete response obtained by bortezomib plus dexamethasone in a patient with relapsed multiple myeloma with multiple plasmacytomas. (2010)
  • Author(s): Fukushima T, Nakamura T, Miki M, Sakai T, Iwao H, Nakajima A, Sawaki T, Fujita Y, Tanaka M, Masaki Y, Hirose Y, Umehara H.
  • Journal Title: Anticancer Res. 30(9) Pages: 3791-3794
  • Peer Reviewed
• [Journal Article] Cisplatin augments FAS-mediated apoptosis through lipid rafts. (2010)
  • Author(s): Huang CR, Jin ZX, Dong L, Tong XP, Yue S, Kawanami T, Sawaki T, Sakai T, Miki M, Iwao H, Nakajima A, Masaki Y, Fukushima Y, Tanaka M, Fujita Y, Nakajima H, Okazaki T, Umehara H.
  • Journal Title: Anticancer Res. 30(6) Pages: 2065-2071
  • Peer Reviewed
• [Journal Article] Vaccination with autoreactive CD4(+)Th1 clones in lupus-prone MRL/Mp-Fas(1pr/1pr) mice. (2009)
  • Author(s): Fujii T, Okada M, Fujita Y, Sato T, Tanaka M, Usui T, Umehara H, Mimori T.
  • Journal Title: J Autoimmun. 33(2) Pages: 125-134
  • Peer Reviewed
• [Journal Article] Aseptic meningitis in mixed connective tissue disease : cytokine and anti-U1RNP antibodies in cerebrospinal fluids from two different cases. (2008)
  • Author(s): Fujita Y, Fujii T, Nakashima R, Tanaka M, Mimori T.
  • Journal Title: Mod Rheumatol. 18(2) Pages: 184-188
  • Peer Reviewed
• [Presentation] Leptin protects B lymphocytes from starvation-induced apoptosis (2010)
  • Author(s): Fujita Y
  • Organizer: 14th International congress of immunology
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2010-08-24
• [Presentation] Leptin protects B lymphocytes from starvation-induced apoptosis (2009)
  • Author(s): Fujita Y.
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-04
• [Presentation] 肥満物質(レプチン)のB細胞に対する抗アポトーシス作用 (2009)
  • Author(s): 藤田義正
  • Organizer: 第53回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2009-04-24