2009 Fiscal Year Final Research Report

Analysis of the distribution and the transmission process of transferable quinolone resistance determinants

Research Project

Project/Area Number	20790712
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Infectious disease medicine
Research Institution	Toho University
Principal Investigator	SAGA Tomoo Toho University, 医学部, 助教 (80459809)
Project Period (FY)	2008 – 2009
Keywords	キノロン耐性化遺伝子 / プラスミド伝達性 / qnr
Research Abstract	Increase of quinolone-resistant bacteria is an important clinical problem. At the beginning of this study, I focused on the transmission and distribution of plasmid-mediated quinolone resistance determinant qnrB, which might cause rapid increase of drug resistant pathogens. Certain strains of Citrobacter species, including type strains or an isolate in pre-antibiotic era, harboured whole-length or partial qnrB-like nucleotide sequence, suggesting that qnrB might have certain relationship with this species. Not only qnrB-like gene itself but also operons neighbouring it seemed involved in stress-response system, implying the possible role of qnrB other than antimicrobial resistance.