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2009 Fiscal Year Final Research Report

Development of novel blood RNA diagnostic system for inflammatory skin disease

Research Project

  • PDF
Project/Area Number 20790824
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionHyogo College of Medicine

Principal Investigator

TSUDA Tatsuya  Hyogo College of Medicine, 医学部, 助教 (80434942)

Project Period (FY) 2008 – 2009
Keywords炎症性皮膚疾患 / 網羅的解析 / 末梢血 / RNAマーカー / 選抜アレイ
Research Abstract

We performed DNA microarray analysis of total RNA obtained from peripheral blood of psoriasis vulgaris and atopic dermatitis patients. We focused on CCL23 and S100P relating with clinical symptoms and other blood data, and tried to develop focused array to detect these two genes with low costs and easy operation. However, developed focused array did not have enough sensitivity.

  • Research Products

    (10 results)

All 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (5 results)

  • [Journal Article] Tetracyclines modulate protease-activated receptor 2-mediated proinflammatory reactions in epidermal keratinocytes.2009

    • Author(s)
      Ishikawa C, Tsuda T, Konishi H, Nakagawa N, Yamanishi K.
    • Journal Title

      Antimicrobial agents and chemotherapy 53巻

      Pages: 1760-1765

    • Peer Reviewed
  • [Journal Article] Identification of preferred substrate sequences for transglutaminase 1-development of a novel peptide that can efficiently detect cross-linking enzyme activity in the skin.2008

    • Author(s)
      Sugimura Y, Hosono M, Kitamura M, Tsuda T, Yamanishi K, Maki M, Hitomi K.
    • Journal Title

      The FEBS Journal 275巻

      Pages: 5667-77

    • Peer Reviewed
  • [Journal Article] Adult cutaneous alveolar rhabdomyosarcoma on the face diagnosed by the expression of PAX3-FKHR gene fusion transcripts.2008

    • Author(s)
      Nakagawa N, Tsuda T, Yamamoto M, Ito T, Futani H, Yamanishi K.
    • Journal Title

      Journal of Dermatology 35巻

      Pages: 462-467

    • Peer Reviewed
  • [Journal Article] A novel point mutation of keratin 17 (KRT17) in a Japanese family with pachyonychia congenita type 2: an RNA-based genetic analysis using a single hair bulb.2008

    • Author(s)
      Tsuda T, Ishikawa C, Nakagawa N, Konishi H, Tarutani M, Matsuki M, Yamanishi K.
    • Journal Title

      British Journal of Dermatology 159巻

      Pages: 730-732

    • Peer Reviewed
  • [Journal Article] Cutaneous malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma) arising in a chronic scalp ulcer of a patient with non-bullous congenital ichthyosiform erythroderma.2008

    • Author(s)
      Fujimoto T, Tsuda T, Yamamoto M, Tarutani M, Natsuaki M, Minami S, Ito T, Kozuka T, Yamanishi K.
    • Journal Title

      Journal of the European Academy of Dermatology and Venereology 23巻

      Pages: 202-203

    • Peer Reviewed
  • [Presentation] 急性腎障害を合併したケラチン10の新規ミスセンス変異をもつ水疱型先天性魚鱗癬様紅皮症2009

    • Author(s)
      山本雅章、津田達也、小西弘江、山西清文
    • Organizer
      日本皮膚科学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      20090424-20090426
  • [Presentation] 膿胞性乾癬に対する白血球除去療法2009

    • Author(s)
      今井康友、古川紗綾佳、津田達也、上田英一郎、山西清文
    • Organizer
      第87回兵庫県皮膚科医会総会・学術集談会
    • Place of Presentation
      生田神社会館、兵庫県
    • Year and Date
      2009-11-28
  • [Presentation] Psoriasis like hyperplastic and inflammatory lesions produced by epidermis specific, inducible activation of Raf in mice.2008

    • Author(s)
      M Tarutani, Y Imai, T Tsuda, K Nakanishi, K Yamanishi
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      京都国際会議場
    • Year and Date
      20080514-20080517
  • [Presentation] Serum calcium-binding S100A8/A9 proteins in patients with psoriatic arthritis are derived from not only the skin lesions but also circulating monocytes.2008

    • Author(s)
      S Aochi, K Tsuji, M Sakaguchi, N Huh, T Tsuda, K Yamanishi, M komine, K Iwatasuki
    • Organizer
      International Investigative Dermatology 2008
    • Place of Presentation
      京都国際会議場
    • Year and Date
      20080514-20080517
  • [Presentation] 瀧澤俊広、トランスグルタミナーゼ1へのアルギニン142点突然変異導入マウスの表現型解析2008

    • Author(s)
      津田達也、松木正人、小西弘江、山西清文
    • Organizer
      第22回表皮細胞研究会
    • Place of Presentation
      ホテル日航東京
    • Year and Date
      2008-12-06

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Published: 2011-06-18   Modified: 2016-04-21  

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