2009 Fiscal Year Final Research Report
Self-monitoring dysfunction in schizophrenia using event related potential studies
| Project/Area Number |
20790832
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ARAKI Tsuyoshi The University of Tokyo, 医学部・附属病院, 講師 (00456120)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 統合失調症 / 事象関連電位 / 脳波 |
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| Research Abstract |
Self monitoring dysfunction in schizophrenia was investigated in this study using event related potentials. The auditory mismatch negativity task was employed and subjects including both patients with schizophrenia and normal controls were participated in this study. The grand mean event related potential waves showed relatively reduced in first episode schizophrenia compared with normal controls but there is no significant difference between groups. Patients with chronic schizophrenia showed reduced MMN and that would suggest that MMN could be one of the biological markers to reflect the progressive change in schizophrenia. We still continue further studies including the longitudinal studies and intra-cranial recording EEG studis.
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