• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2009 Fiscal Year Final Research Report

Role of splicing factors in the pathogenesis of mood disorders

Research Project

  • PDF
Project/Area Number 20790844
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionYamaguchi University

Principal Investigator

UCHIDA Shusaku  Yamaguchi University, 大学院・医学系研究科, 助教 (10403669)

Project Period (FY) 2008 – 2009
Keywords気分障害 / 選択的スプライシング / 遺伝子発現
Research Abstract

In this study, we examined the expression analyses of genes which are involved in the regulation of splicing and transcription in mood disorder patients. We found that the expression of SRp20, nPTB, and HDACs mRNAs were altered in patients with mood disorders. Thus our results suggest the aberrant regulations of alternative splicing and transcription in mood disorder.

  • Research Products

    (11 results)

All 2010 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (3 results)

  • [Journal Article] Altered gene expression of histone deacetylases in mood disorder patients.2010

    • Author(s)
      Hobara T, Uchida S, Otsuki K, Matsubara T, Funato H, Matsuo K, Suetsugi M, Watanabe Y.
    • Journal Title

      Journal of Psychiatric Research 44

      Pages: 378-384

    • Peer Reviewed
  • [Journal Article] Maternal and genetic factors in stress-resilient and -vulnerable rats: A cross-fostering study.2010

    • Author(s)
      Uchida S, Hara K, Kobayashi A, Otsuki K, Hobara T, Yamagata H, Watanabe Y.
    • Journal Title

      Brain Research 1316

      Pages: 43-50

    • Peer Reviewed
  • [Journal Article] Aberrant REST-mediated transcriptional regulation in major depressive disorder2010

    • Author(s)
      Otsuki K, Uchida S, Wakabayashi Y, Matsubara T, Hobara T, Funato H, Watanabe Y.
    • Journal Title

      Journal of Psychiatric Research 44

      Pages: 263-270

    • Peer Reviewed
  • [Journal Article] Characterization of the vulnerability to repeated restraint stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor.2008

    • Author(s)
      Uchida S, Nishida A, Hara K, Kamemoto T, Suetsugi M, Fujimoto M, Watanuki T, Wakabayashi Y, Otsuki K, McEwen BS, Watanabe Y.
    • Journal Title

      European Journal of Neuroscience 27

      Pages: 2250-2261

    • Peer Reviewed
  • [Journal Article] Altered expression of neurotrophic factors in patients with major depression.2008

    • Author(s)
      Otsuki K, Uchida S, Watanuki T, Wakabayashi Y, Fujimoto M, Matsubara T, Funato H, Watanabe Y.
    • Journal Title

      Journal of Psychiatric Research 42

      Pages: 1145-1153

    • Peer Reviewed
  • [Journal Article] Reduced expression of glyoxalase-1 mRNA in mood disorder patients.2008

    • Author(s)
      Fujimoto M, Uchida S, Watanuki T, Wakabayashi Y, Otsuki K, Matsubara T, Suetsugi M, Funato H, Watanabe Y.
    • Journal Title

      Neuroscience Letters 438

      Pages: 196-199

    • Peer Reviewed
  • [Journal Article] State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders.2008

    • Author(s)
      Wakabayashi Y, Uchida S, Funato H, Matsubara T, Watanuki T, Otsuki K, Fujimoto M, Nishida A., Watanabe Y.
    • Journal Title

      Prog. Neuropsychopharmacol. Biol. Psychiatry 32

      Pages: 1199-1205

    • Peer Reviewed
  • [Journal Article] Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients.2008

    • Author(s)
      Watanuki T, Funato H, Uchida S, Matsubara T, Kobayashi A, Wakabayashi Y, Otsuki K, Nishida A, Watanabe Y
    • Journal Title

      Journal of Affective Disorders 110

      Pages: 62-69

    • Peer Reviewed
  • [Presentation] HDAC2-mediated epigenetic repression of the GDNF gene in the ventral striatum modulates behavioral vulnerability to stress.2009

    • Author(s)
      Shusaku Uchida, et al.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      シカゴ
    • Year and Date
      2009-10-19
  • [Presentation] HDAC2-mediated epigenetic repression of the GDNF gene in the striatum modulates behavioral vulnerability to stress.2009

    • Author(s)
      Shusaku Uchida, et al.
    • Organizer
      第32回日本神経科学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
  • [Presentation] Epigenetic regulation of GDNF gene in a mouse model of depression and antidepressant action.2009

    • Author(s)
      Shusaku Uchida, et al.
    • Organizer
      第31回日本生物学的精神医学会年会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-24

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi