2010 Fiscal Year Final Research Report
A study of genome instability and imprinting in schizophrenia.
| Project/Area Number |
20790859
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Teikyo University |
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Principal Investigator |
UENO Mikako Teikyo University, 医学部, 研究員 (00398736)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 統合失調症 / 転移因子 / LINE-1 / Alu / de novo変異 / ゲノム不安定性 / インプリンティング / 経時的変異 |
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| Research Abstract |
We hypothesize that the genetic basis for schizophrenia is mutational events mediated by the mobile elements causing genome instability under the abnormal methylation. These dynamics of mobile elements is not fully fixed, and might be progressively in terms of imprinting or after event onset. Herein, we have attempted the screening of de novo mutations mediated by LINE-1 and Alu in patients from the schizophrenia trios and the sequential samples from patient and control subject. Consequently, we have identified the de novo mutation mediated by LINE-1 and Alu which were specific to patient. Our results suggested that the dynamics of mobile elements might be one of the risk factors for schizophrenia. Further research using screenings of de novo mutations mediated by mobile elements from various samples is needed to clarify the etiology in schizophrenia.
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