2010 Fiscal Year Final Research Report
Signaling mechanism and the role of HGF for radiation-induced liver damage
| Project/Area Number |
20790880
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
IMAEDA Masumi Gunma University, 医学部, 医員 (30451727)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 放射線照射後肝障害 / TGF-beta |
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| Research Abstract |
In the control (0Gy) and 15Gy groups, all mice survived but 80% of the mice in the 30Gy group died 6 months after irradiation. TGF-beta expression was significantly induced from 1 day to 4 weeks in the 15Gy and 30Gy groups compared with the control and 5Gy groups. Plasma albumin was decreased immediately after liver irradiation but was gradually resolved 4 weeks after irradiation. Similarly, recovery from liver damage 4 weeks after 30Gy and 15Gy irradiation was observed using the immunohistochemical staining method but no liver fibrosis was detected. TGF-beta may predict radiation-induced liver damage and death from the damage without a close relationship with liver fibrosis.
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