2009 Fiscal Year Final Research Report
Visualization of microscopic structure and cell membrane function based on diffusion of water molecule in biological tissue
| Project/Area Number |
20790884
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IMAE Toshikazu The University of Tokyo, 医学部・附属病院, 診療放射線技師 (80420222)
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| Co-Investigator(Renkei-kenkyūsha) |
SHINOHARA Hiroyuki 首都大学東京, 人間健康科学研究科, 教授 (90138488)
SEKINO Masaki 東京大学, 新領域創成科学研究科, 助教 (20401036)
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| Project Period (FY) |
2008 – 2009
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| Keywords | MRI / 拡散 / 生体内水分子 / 細胞膜機能 / 可視化 |
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| Research Abstract |
The signal intensity of diffusion-weighted imaging is sensitive to the intra- and extracellular diffusion coefficient of water and cell membrane permeability. We proposed a method to estimate noninvasively the membrane permeability and intracellular diffusion coefficient. The estimated membrane permeability of normal human brain and infarcted rat brain were 76±9μm/sec and 58μm/sec, respectively. The result indicates that injury due to the cerebral infarction causes the decline of the cell membrane function.
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