2009 Fiscal Year Final Research Report
Analysis of Molecular mechanisms and radiosensitizing effect of Gimeracil.
| Project/Area Number |
20790902
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
MASANORI Someya Sapporo Medical University, 医学部, 助教 (60404711)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 放射線治療生物学 |
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| Research Abstract |
We analyzed molecular mechanisms of radiosensitizing effect of Gimeracil as a clinically expecting therapeutic drug. By using methods of colony formation assay and radiation-induced foci formation assay, we proved that gimeracil partially inhibits homologous recombination in the DNA double strand break repair mechanism and therefore the radiosensitizing effect can be obtained.
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